From the world’s #1 selling OTC cough and cold medicine brand and the makers of NyQuil, Vicks NyQuil Sinus Pain & Headache liquid relieves sinus pain & headache, runny nose, and sneezing, so you can rest. This nighttime sinus pain & headache liquid medicine contains two powerful medicines: Acetaminophen (pain reliever/fever reducer) to relieve sinus pain and headache and Doxylamine Succinate (antihistamine) to relieve runny nose and sneezing at night. When sinus pain and headache keep you up at night, try Vicks NyQuil Sinus Pain & Headache liquid. Suitable for adults and children 6+ years. Follow dosing instructions. Vicks has been trusted since 1894 to help relieve your respiratory symptoms. Nicholas Hall’s global CHC database, DB6 2025.